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KMID : 1041220070490020067
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Journal of Sericultural and Entomological Science
2007 Volume.49 No. 2 p.67 ~ p.70
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Dietary Effect of Silk Protein on Colon Cancer of Animal
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Yeo Joo-Hong
Lee Kwang-Gill
Woo Soon-Ok
Kweon Hae-Yong
Han Sang-Mi
Park Kyung-Ho
Kim Sung-Su
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Abstract
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This study was done for the dietary effect of silk protein, molecular controlled silk sericin and silk fibroin, on colon cancer of animal. The ICR mice were given weekly injections of 1,2-dimethylhydrazine (DMZ) for the initial 10 mg/kg with four weeks, and fed a diets supplemented with 3% (v/v) molecular controlled sericin and fibroin for 6 weeks, respectively. Then, the body weight, efficiency of dietary, typical histologic appearance of animal colon tissue and COX-2 effect were studied, too. Molecular controlled sericin protein are shown more higher dietary effect on animal colon cancer than fibroin supplemental case. The results suggest a potential usefulness of sericin as a chemopreventive for colon carcinogenesis and the development functional food.
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KEYWORD
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Silk protein, Sericin, Fibroin, Dietary effect, Animal colon cancer
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